B细胞和T细胞筛选

定义

B细胞和T细胞筛选 is a laboratory test to determine the amount of B and T lymphocytes in the blood.

选择的名字

E-rosetting; T and B lymphocyte assays; B and T lymphocyte assays

How the Test is Performed

A 需要血液样本.

Blood could also be obtained by 毛细管样品 (fingerstick or heel stick in infants).

After the blood is drawn, it goes through a two-step process. First, the lymphocytes are separated from other blood parts. Once the cells are separated, identifiers are added to distinguish between T and B cells.

How to Prepare for the Test

Tell your health care provider if you have had any of the following, which might affect your T and B cell count:

• 化疗
• 艾滋病毒/艾滋病
• 放射治疗
• Recent or current infection
• 类固醇治疗
• 压力
• 手术

考试的感觉如何

When the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.

Why the Test is Performed

Your provider may order this test if you have signs of certain diseases that weaken the immune system. It may also be used to distinguish between cancerous and noncancerous disease, particularly cancers that involve the blood and bone marrow.

The test may also be used to determine how well treatment for certain conditions is working.

正常的结果

Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your provider about the meaning of your specific test results.

What Abnormal Results Mean

Abnormal B and T cell counts may suggest a possible disease. Further testing is needed to confirm a diagnosis.

An increased T cell count may be due to:

• Cancer of white blood cells called lymphoblasts (acute lymphoblastic leukemia)
• Cancer of white blood cells called lymphocytes (chronic lymphocytic leukemia)
• A viral infection called 传染性单核细胞增多
• Blood cancer that starts in the plasma cells in the bone marrow (多发性骨髓瘤)
• Syphilis, a sexually transmitted disease (STD)
• Toxoplasmosis, an infection due to a parasite
• 肺结核

An increased B cell count may be due to:

• Chronic lymphocytic leukemia
• 迪格奥尔格综合征
• 多发性骨髓瘤
• Waldenström macroglobulinemia

A decreased T cell count may be due to:

• Congenital T-cell deficiency disease, 比如Nezelof综合征, 迪格奥尔格综合征, or Wiskott-Aldrich syndrome
• Acquired T-cell deficiency states, such as HIV infection or HTLV-1 infection
• B cell proliferative disorders, such as chronic lymphocytic leukemia or Waldenström macroglobulinemia

A decreased B cell count may be due to:

• 艾滋病毒/艾滋病
• Acute lymphoblastic leukemia
• Immunodeficiency disorders
• Treatment with certain medicines

风险

Veins and arteries vary in size from one person to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.

Other risks associated with having blood drawn are slight but may include:

• 大出血
• Fainting or feeling lightheaded
• Hematoma (blood accumulating under the skin)
• Infection (a slight risk any time the skin is broken)

参考文献

Liebman HA, Tulpule A. Hematologic manifestations of 艾滋病毒/艾滋病. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 7日艾德. Philadelphia, PA: Elsevier; 2018:chap 157.

Riley RS, Mageau R, Ben-Ezra J. Laboratory evaluation of the cellular immune system. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24日艾德. Philadelphia, PA: Elsevier; 2022:chap 46.